Get ready for a creamy, spicy, cheesy pasta dish that feels like a warm, garlicky hug in a bowl. This Chicken Penne in Cajun Mozzarella Garlic Butter Sauce is the ultimate weeknight indulgence—bold in flavor, rich in texture, and unbelievably satisfying.

It’s got perfectly seared chicken, pasta cooked just right, and a luscious sauce made of garlic butter, cream, mozzarella, and Cajun spice. One bite and you’ll know: this is not your average pasta night.

Why You’ll Love Chicken Penne in Cajun Mozzarella Garlic Butter Sauce

This recipe isn’t just about the ingredients—it’s about creating moments. You’ll love it because it brings together spicy comfort, creamy goodness, and cheesy satisfaction all in one bowl. It’s quick enough for a weeknight and impressive enough for guests. And that sauce? Trust me—you’ll want to lick the plate.

Chef’s Pro Tips for Perfect Results

Want to nail this dish on your very first try? Here are some insider secrets…

• Pound or slice the chicken evenly so it cooks quickly and stays juicy.
• Use freshly shredded mozzarella for smoother melting and creamier texture.
• Reserve some pasta water to thin out the sauce without losing flavor.
• Layer your Cajun seasoning—season the chicken and the sauce separately for maximum flavor.

Ingredients

1. 2 boneless skinless chicken breasts, sliced into strips
2. 1 tablespoon Cajun seasoning (plus extra to taste)
3. Salt and black pepper, to taste
4. 2 tablespoons olive oil
5. 10 oz penne pasta
6. 3 tablespoons unsalted butter
7. 4 cloves garlic, minced
8. 1/2 teaspoon red pepper flakes (optional)
9. 1 cup heavy cream
10. 1/2 cup chicken broth
11. 1 1/2 cups shredded mozzarella cheese
12. 1/4 cup grated Parmesan cheese
13. 1/4–1/2 cup reserved pasta water
14. Chopped fresh parsley, for garnish

Instructions

Let’s dive into the steps to create this flavorful masterpiece…

1. Cook the pasta in salted water according to package directions. Reserve 1/2 cup pasta water, then drain and set aside.
2. Season the chicken with Cajun seasoning, salt, and pepper.
3. Heat olive oil in a large skillet over medium heat. Cook chicken until browned and fully cooked, about 4–5 minutes per side. Remove and set aside.
4. In the same skillet, melt butter. Add garlic and red pepper flakes and sauté for 1–2 minutes until fragrant.
5. Add chicken broth and cream and bring to a gentle simmer.
6. Stir in mozzarella and Parmesan, letting it melt into a smooth, creamy sauce.
7. Return the chicken to the skillet and stir to coat in the sauce.
8. Add cooked penne pasta, tossing to combine. Add reserved pasta water as needed to loosen the sauce.
9. Taste and adjust seasoning, adding more Cajun spice if desired.
10. Garnish with parsley and serve hot!

Texture & Flavor Secrets

This dish is a total flavor bomb. The Cajun seasoning adds warmth and spice, while the mozzarella and cream bring richness and body. The chicken is juicy and golden, the pasta is perfectly coated, and the garlic butter base ties it all together with melt-in-your-mouth magic. Every bite is creamy, spicy, savory bliss.

How to Serve Chicken Penne in Cajun Mozzarella Garlic Butter Sauce

This dish pairs wonderfully with various sides…

• Garlic knots or cheesy breadsticks
• A crisp Caesar or arugula salad
• Steamed broccoli or roasted asparagus
• A cold glass of lemonade or white wine

Creative Leftover Transformations

Don’t let leftovers go to waste! You can…

• Add a splash of cream and reheat for another creamy pasta dinner
• Make a pasta bake—top with mozzarella and broil until bubbly
• Use in a wrap with spinach for a Cajun chicken pasta wrap
• Serve cold as a spicy pasta salad with a dollop of ranch

Additional Tips

Here are some extra tips to make your pasta extra fabulous:

• Add spinach, sun-dried tomatoes, or mushrooms for bonus flavor
• Use rotisserie chicken for a faster prep
• Swap penne for bowtie, rigatoni, or fettuccine
• Top each serving with extra Parmesan and red chili flakes for heat and flair

Make It a Showstopper (Presentation Ideas)

Want to wow your guests?

• Serve in shallow white pasta bowls with a swirl of sauce on top
• Sprinkle fresh chopped parsley and cracked black pepper over each serving
• Add a lemon wedge on the side for color and contrast
• Plate with grilled garlic bread stacked beside the pasta

FAQ’s

1. Can I use pre-cooked chicken?
   Yes—just slice and warm it in the sauce before serving.
2. Is this dish spicy?
   It has a mild to medium Cajun kick—adjust by using more or less Cajun spice and red pepper flakes.
3. Can I use milk instead of cream?
   You can, but it won’t be as rich. Use whole milk and add a little more Parmesan to thicken.
4. Is there a substitute for mozzarella?
   Provolone, Fontina, or Monterey Jack can work—just avoid fresh mozzarella as it’s too watery.
5. Can I make this vegetarian?
   Yes! Use plant-based protein or sautéed mushrooms instead of chicken, and veggie broth in place of chicken broth.
6. How do I store leftovers?
   Refrigerate in an airtight container for up to 4 days.
7. Can I freeze it?
   Not ideal—the sauce may separate when thawed. Best enjoyed fresh or refrigerated.
8. What’s the best Cajun seasoning?
   Store-bought blends like Slap Ya Mama or homemade mixes with paprika, garlic powder, onion powder, thyme, and cayenne are great.
9. Will the mozzarella make the sauce stringy?
   Not if you melt it slowly and stir well. Shredded, low-moisture mozzarella works best.
10. How can I make it extra saucy?
    Double the cream and broth, and add extra pasta water if needed.

Conclusion

Chicken Penne in Cajun Mozzarella Garlic Butter Sauce is everything you love about comfort food—rich, spicy, cheesy, and bursting with flavor. It’s quick enough for weeknights but fancy enough for guests. Serve it hot, twirl it high, and watch it disappear—because this dish is a guaranteed crowd-pleaser.

Print

Watch How to Make Chicken Penne in Cajun Mozzarella Garlic Butter Sauce